Respiratory Depressant Effects of Fentanyl Analogs
نویسندگان
چکیده
منابع مشابه
Mechanism-based pharmacokinetic-pharmacodynamic modeling of the respiratory-depressant effect of buprenorphine and fentanyl in rats.
The purpose of this investigation was to develop a mechanism-based pharmacokinetic/pharmacodynamic (PK/PD) model to predict the time course of respiratory depression following administration of opioids in rats. The proposed model is based on receptor theory and aims at the separate characterization of biophase distribution and receptor association/dissociation kinetics as determinants of hyster...
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To the Editor: With regard to the letter on the abovementioned subject by Cajee and Buchanan,' I' should like to make the following comments: While the articles by Adams and Pybus' and Becker et al.' are valuable and raise doubts about fentanyl's being a 'shortacting' drug, perhaps the most telling evidence against these doubts is contained in an article by Morgan et al." which reported a study...
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There are errors in the Funding section. The publisher apologizes for these errors. The correct funding information is as follows: Dr. Caroline Jolley is supported by a NIHR Academic Clinical Lectureship in Respiratory Medicine. Professor John Strang is supported by the National Institute for Health Research (NIHR) Biomedical Research Centre for Mental Health at South London and Maudsley NHS Fo...
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Opioids are respiratory depressants and heroin/opioid overdose is a major contributor to the excess mortality of heroin addicts. The individual and situational variability of respiratory depression caused by intravenous heroin is poorly understood. This study used advanced respiratory monitoring to follow the time course and severity of acute opioid-induced respiratory depression. 10 patients (...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2021
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2021.35.s1.03662